Analysis of the performance of polarimetric PSI over distributed scatterers with Sentinel-1 data

Sentinel−1 (S1) data enables effective monitoring of displacements using persistent scatterer interferometry (PSI). S1 includes VV and VH polarization channels, allowing us to apply polarimetric techniques to PSI. In short, polarimetric PSI (PolPSI) exploits the available polarization channels to enhance the identification and processing of measurement points including persistent scatterers (PS) and distributed scatterers (DS). Previous works have shown the benefits of using PolPSI for PS points with S1 data, but the corresponding analysis for DS is missing. DS points are processed by finding a neighborhood of statistically homogeneous pixels (SHP) and averaging the phase within that neighborhood. In this work we show how dual-polarimetric data are stricter on the selection of the SHP group than single-polarimetric data. Thanks to the information added by the second channel, different land covers are not mixed in the SHP group. As a result, the number of points in the SHP groups is generally smaller than with VV alone, but they are more reliable. The impact of this strategy on the resulting deformation estimates is also investigated in this work, showing that the deformation areas are fully preserved and the influence of nearby pixels associated with other scene elements is avoided.This work was supported in part by the European Funds for Regional Development and by the Spanish Ministry of Science and Innovation (Agencia Estatal de Investigación, AEI) with Project PID2020-117303GB-C22/AEI/10.13039/501100011033, and in part by the Generalitat Valenciana, Conselleria de Innovacion, Universidades, Ciencia y Sociedad Digital with Project CIAICO/2021/335. The research was also partially performed in the ESA-MOST China DRAGON-5 project ref. 59339

Mapping the 2021 October Flood Event in the Subsiding Taiyuan Basin By Multi-Temporal SAR Data

A flood event induced by heavy rainfall hit the Taiyuan basin in north China in early October of 2021. In this study, we map the flood event process using the multi-temporal synthetic aperture radar (SAR) images acquired by Sentinel-1. First, we develop a spatiotemporal filter based on low-rank tensor approximation (STF-LRTA) for removing the speckle noise in SAR images. Next, we employ the classic log-ratio change indicator and the minimum error threshold algorithm to characterize the flood using the filtered images. Finally, we relate the flood inundation to the land subsidence in the Taiyuan basin by jointly analyzing the multi-temporal SAR change detection results and interferometric SAR (InSAR) time-series measurements (pre-flood). The validation experiments compare the proposed filter with the Refined-Lee filter, Gamma filter, and an SHPS-based multi-temporal SAR filter. The results demonstrate the effectiveness and advantage of the proposed STF-LRTA method in SAR despeckling and detail preservation, and the applicability to change scenes. The joint analyses reveal that land subsidence might be an important contributor to the flood event, and the flood recession process linearly correlates with time and subsidence magnitude.This work was financially supported by the National Natural Science Foundation of China (grant numbers 41904001 and 41774006), the China Postdoctoral Science Foundation (grant number 2018M640733), the National Key Research and Development Program of China (grant number 2019YFC1509201), and the National Postdoctoral Program for Innovative Talents (grant number BX20180220)

Assessment of the Contribution of Polarimetric Persistent Scatterer Interferometry on Sentinel-1 Data

Time series of Sentinel-1 data are widely used for monitoring displacements of the Earth surface using persistent scatterer interferometry. By default over land, Sentinel-1 images include two polarimetric channels: VV and VH. However, most works in this application exploit only the VV channel, whereas the VH channel is discarded for its lower amplitude. Thanks to the development of polarimetric persistent scatterer interferometry methods, one can integrate multi-polarisation channels into a single optimal one. Previous studies proved that the number and spatial density of measurement points is increased. In this work, we explore the reason why the VH channel increases the number of measurement points when using the amplitude dispersion ( DA ) as selection criterion. Results obtained over three geographical locations show that the VH channel helps in two ways. In first place, the mean amplitude is increased for targets which have higher amplitude in VH channel, usually associated with rotated elements in the scene. In second place, and more importantly, the amplitude dispersion is decreased over many areas for which the VV channel exhibits fluctuations and peaks. Thanks to the insensitivity of the VH channel to these scene changes, it provides additional measurement points which are reliable despite their low amplitude. The increment of measurement points not only extends the spatial density and enables the detection of active deformation areas not found in the VV results, but also provides more accurate results than only using the VV channel, thanks to the increased density of points, which helps the deformation estimation.This work was supported by the Spanish Ministry of Science and Innovation (State Agency of Research, AEI) and the European Funds for Regional Development (EFRD) under Projects PID2020-117303GB-C21 and PID2020-117303GB-C22. The research was carried out partially in the framework of the ESA-MOST China DRAGON-5 project with ref. 59339

Advances on the investigation of landslides by space-borne synthetic aperture radar interferometry

Landslides are destructive geohazards to people and infrastructure, resulting in hundreds of deaths and billions of dollars of damage every year. Therefore, mapping the rate of deformation of such geohazards and understanding their mechanics is of paramount importance to mitigate the resulting impacts and properly manage the associated risks. In this paper, the main outcomes relevant to the joint European Space Agency (ESA) and the Chinese Ministry of Science and Technology (MOST) Dragon-5 initiative cooperation project ID 59,339 “Earth observation for seismic hazard assessment and landslide early warning system” are reported. The primary goals of the project are to further develop advanced SAR/InSAR and optical techniques to investigate seismic hazards and risks, detect potential landslides in wide regions, and demonstrate EO-based landslide early warning system over selected landslides. This work only focuses on the landslide hazard content of the project, and thus, in order to achieve these objectives, the following tasks were developed up to now: a) a procedure for phase unwrapping errors and tropospheric delay correction; b) an improvement of a cross-platform SAR offset tracking method for the retrieval of long-term ground displacements; c) the application of polarimetric SAR interferometry (PolInSAR) to increase the number and quality of monitoring points in landslide-prone areas; d) the semiautomatic mapping and preliminary classification of active displacement areas on wide regions; e) the modeling and identification of landslides in order to identify triggering factors or predict future displacements; and f) the application of an InSAR-based landslide early warning system on a selected site. The achieved results, which mainly focus on specific sensitive regions, provide essential assets for planning present and future scientific activities devoted to identifying, mapping, characterizing, monitoring and predicting landslides, as well as for the implementation of early warning systems.This work was supported by the ESA-MOST China DRAGON-5 project with ref. 59339, by the Spanish Ministry of Science and Innovation, the State Agency of Research (AEI), and the European Funds for Regional Development under grant [grant number PID2020-117303GB-C22], by the Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital in the framework of the project CIAICO/2021/335, by the Natural Science Foundation of China [grant numbers 41874005 and 41929001], the Fundamental Research Funds for the Central University [grant numbers 300102269712 and 300102269303], and China Geological Survey Project [grant numbers DD20190637 and DD20190647]. Xiaojie Liu and Liuru Hu have been funded by Chinese Scholarship Council Grants Ref. [grant number 202006560031] and [grant number 202004180062], respectively

Low Cell-Matrix Adhesion Reveals Two Subtypes of Human Pluripotent Stem Cells.

We show that a human pluripotent stem cell (hPSC) population cultured on a low-adhesion substrate developed two hPSC subtypes with different colony morphologies: flat and domed. Notably, the dome-like cells showed higher active proliferation capacity and increased several pluripotent genes' expression compared with the flat monolayer cells. We further demonstrated that cell-matrix adhesion mediates the interaction between cell morphology and expression of KLF4 and KLF5 through a serum response factor (SRF)-based regulatory double loop. Our results provide a mechanistic view on the coupling among adhesion, stem cell morphology, and pluripotency, shedding light on the critical role of cell-matrix adhesion in the induction and maintenance of hPSC

Fumarylacetoacetate Hydrolase Knock-out Rabbit Model for Hereditary Tyrosinemia Type 1.

Hereditary tyrosinemia type 1 (HT1) is a severe human autosomal recessive disorder caused by the deficiency of fumarylacetoacetate hydroxylase (FAH), an enzyme catalyzing the last step in the tyrosine degradation pathway. Lack of FAH causes accumulation of toxic metabolites (fumarylacetoacetate and succinylacetone) in blood and tissues, ultimately resulting in severe liver and kidney damage with onset that ranges from infancy to adolescence. This tissue damage is lethal but can be controlled by administration of 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC), which inhibits tyrosine catabolism upstream of the generation of fumarylacetoacetate and succinylacetone. Notably, in animals lacking FAH, transient withdrawal of NTBC can be used to induce liver damage and a concomitant regenerative response that stimulates the growth of healthy hepatocytes. Among other things, this model has raised tremendous interest for the in vivo expansion of human primary hepatocytes inside these animals and for exploring experimental gene therapy and cell-based therapies. Here, we report the generation of FAH knock-out rabbits via pronuclear stage embryo microinjection of transcription activator-like effector nucleases. FAH-/- rabbits exhibit phenotypic features of HT1 including liver and kidney abnormalities but additionally develop frequent ocular manifestations likely caused by local accumulation of tyrosine upon NTBC administration. We also show that allogeneic transplantation of wild-type rabbit primary hepatocytes into FAH-/- rabbits enables highly efficient liver repopulation and prevents liver insufficiency and death. Because of significant advantages over rodents and their ease of breeding, maintenance, and manipulation compared with larger animals including pigs, FAH-/- rabbits are an attractive alternative for modeling the consequences of HT1.Wellcome Trus

Microinjection Manipulation Resulted in the Increased Apoptosis of Spermatocytes in Testes from Intracytoplasmic Sperm Injection (ICSI) Derived Mice

The invention of intracytoplasmic sperm injection (ICSI) has possibly been the most important development in reproductive medicine, one that has given hope to thousands of infertile couples worldwide. However, concerns remain regarding the safety of this method since it is a more invasive procedure than in vitro fertilization (IVF), since a spermatozoon is injected into the oocyte cytoplasm. Using mice derived from IVF technology as a control, we assessed the influence of invasive microinjection in the process of transferring sperm into oocyte cytoplasm in ICSI procedure on the development and physiologic function of resultant offspring. Our results demonstrated that mice produced from ICSI and IVF had no significant difference in phenotypic indices including body weight, forelimb physiology, and learning and memory ability. However, increased spermatocyte apoptosis was observed in the testis of adult ICSI mice, when compared with IVF mice. And, decreased testis weight and marked damage of spermatogenic epithelia were found in aged ICSI mice. Furthermore, proteomic analysis verified that most of the differentiated proteins in testes between adult ICSI and IVF mice were those involved in regulation of apoptosis pathways. Our results demonstrated that the microinjection manipulation used in the ICSI procedure might pose potential risks to the fertility of male offspring. The changed expression of a series of proteins relating to apoptosis or proliferation might contribute to it. Further studies are necessary to better understand all the risks of ICSI

It Was All Planned . . . Now What? Claiming Agency in Later Life in Reforming China

This study explores the social construction of agency and wellbeing among 20 Chinese urban retirees aged between 50 and 82 years old (averaging 67), with a special focus on the impact of earlier life experiences in shaping later-life pathways. Today\u27s retirees in urban China have experienced the communist collectivist ideology during the Mao era as well as the changes to everyday life brought about by the economic transformation from centrally planned socialism to a market-orientated economy. Thereby, life in retirement for Chinese elders becomes more than just an issue of dealing with increases in discretionary time after exit from full-time work, but also one of making sense of their earlier life experiences in the midst of dramatic social changes. A grounded theory approach with semi-structured, in-depth, face-to-face interviews was used for data collection and analysis. Three interrelated themes emerged: (a) reminiscence as a mechanism of meaning-making, (b) discovery and exercise of agency in later life in contrast to a rigidly structured earlier life, and (c) varying pathways to constructing the life-stage of retirement. The findings have refuted gerontological literature and public discourse that often portray Chinese elders as passive care recipients or helpless dependants. Further, the present study has practical implications for developing policies, designing programmes and providing services to improve the quality of life for today\u27s older Chinese people

Toward a Discourse Shift in Social Gerontology: From Successful Aging to Harmonious Aging

Successful aging, though controversial, is used as an overarching conceptual framework in social gerontology. In this theory critique, the discourse of successful aging is identified as problematic with respect to four dimensions. First, successful aging is ageist in nature, and it produces a disharmony between body and mind. Second, successful aging,with the emphasis on quantifiable activities driven by the “busy ethic,” overlooks the deeper concern of quality experience. Third, the capitalist and consumerist components of successful aging are under-addressed. Fourth, successful aging is a discourse developed upon Western (specifically American) values and thus may not readily apply to other cultures. Harmonious aging, as proposed, is inspired by the Yin–Yang philosophy. Harmony refers to the balance based on differences instead of uniformity. This new discourse aims to recognize the challenges and opportunities of old age itself, ease the tension between activity and disengagement theories, heal the integrity of body and mind, and emphasize the interdependent nature of human beings. The call for the discourse shift attempts to promote intellectual exploration of what constitutes a good old age and to capture more cross-cultural diversities in the context of global aging. This theoretical endeavor is important to change the status quo of gerontology as being “data rich but theory poor,” and to contribute to cross-cultural gerontological research, education and communication

Electrospun Blank Nanocoating for Improved Sustained Release Profiles from Medicated Gliadin Nanofibers

Nanomaterials providing sustained release profiles are highly desired for efficacious drug delivery. Advanced nanotechnologies are useful tools for creating elaborate nanostructure-based nanomaterials to achieve the designed functional performances. In this research, a modified coaxial electrospinning was explored to fabricate a novel core-sheath nanostructure (nanofibers F2), in which a sheath drug-free gliadin layer was successfully coated on the core ketoprofen (KET)-gliadin nanocomposite. A monolithic nanocomposite (nanofibers F1) that was generated through traditional blending electrospinning of core fluid was utilized as a control. Scanning electron microscopy demonstrated that both nanofibers F1 and F2 were linear. Transmission electron microscopy verified that nanofibers F2 featured a clear core-sheath nanostructure with a thin sheath layer about 25 nm, whereas their cores and nanofibers F1 were homogeneous KET-gliadin nanocomposites. X-ray diffraction patterns verified that, as a result of fine compatibility, KET was dispersed in gliadin in an amorphous state. In vitro dissolution tests demonstrated that the thin blank nanocoating in nanofibers F2 significantly modified drug release kinetics from a traditional exponential equation of nanofibers F1 to a zero-order controlled release model, linearly freeing 95.7 ± 4.7% of the loaded cargoes over a time period of 16 h